Clinical Aspects and Molecular Basis of Primary Deficiencies of Complement Component C3 and Its Regulatory Proteins Factor I and Factor H

Scand J Immunol. 2006 Mar;63(3):155-68. doi: 10.1111/j.1365-3083.2006.01729.x.

Abstract

The complement system participates in both innate and acquired immune responses. Deficiencies in any of the protein components of this system are generally uncommon and require specialized services for diagnosis. Consequently, complement deficiencies are clinically underscored and may be more common than is normally estimated. As C3 is the major complement component and participates in all three pathways of activation, it is fundamental to understand all the clinical consequences observed in patients for which this protein is below normal concentration or absent in the serum. C3 deficiencies are generally associated with higher susceptibility to severe infections and in some cases with autoimmune diseases such as systemic lupus erythematosus. Here, we review the main clinical aspects and the molecular basis of primary C3 deficiency as well as the mutations in the regulatory proteins factor I and factor H that result in secondary C3 deficiencies. We also discuss the use of animal models to study these deficiencies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Afibrinogenemia / genetics*
  • Animals
  • Autoimmune Diseases / complications
  • Complement Activation
  • Complement C3 / deficiency*
  • Complement C3 / genetics
  • Complement Factor H / deficiency*
  • Complement Factor H / genetics
  • Fibrinogen / genetics
  • Humans
  • Immunologic Deficiency Syndromes / complications
  • Immunologic Deficiency Syndromes / genetics
  • Infections / immunology
  • Models, Animal

Substances

  • Complement C3
  • Complement Factor H
  • Fibrinogen