Mitochondrial import receptors for precursor proteins

Trends Biochem Sci. 1991 Feb;16(2):63-7. doi: 10.1016/0968-0004(91)90026-r.


The specific targeting of precursor proteins synthesized in the cytosol to various cell organelles is a central aspect of intracellular protein traffic. Several hundred different proteins are imported from the cytosol into the mitochondria. Recent studies have identified the mitochondrial outer membrane proteins MOM19, MOM72, MOM38 (approximately ISP42) and p32 which have a role in initial steps of protein import. The first three components are present in a multi-subunit complex that catalyses recognition and membrane insertion of precursor proteins.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport, Active
  • Fungal Proteins*
  • Membrane Proteins*
  • Mitochondria / metabolism*
  • Protein Precursors / metabolism*
  • Receptors, Cell Surface / metabolism*
  • Receptors, Cytoplasmic and Nuclear*


  • Fungal Proteins
  • MOM19 protein, Neurospora crassa
  • Membrane Proteins
  • Protein Precursors
  • Receptors, Cell Surface
  • Receptors, Cytoplasmic and Nuclear