Short-term tumor control and acute toxicity after stereotactic radiosurgery for glomus jugulare tumors

Otolaryngol Head Neck Surg. 2006 Mar;134(3):437-42. doi: 10.1016/j.otohns.2005.10.040.

Abstract

Objective: Glomus jugulare tumors (GJT) have traditionally been treated by surgery or fractionated external beam radiation therapy (XRT). This study evaluates acute toxicity and short-term efficacy of single-fraction stereotactic radiosurgery (SRS) for the treatment of GJT.

Study design and setting: Eight patients (age range 28-74) with GJT underwent SRS (Brainlab linear accelerator) as primary treatment. A nominal dose of 15-16 Gy was prescribed.

Results: After undergoing SRS, 7 of 8 patients (87.5%) reported complete resolution of presenting symptoms. Follow-up MRIs showed tumor stabilization in 100% of patients. Transient vertigo occurred in one patient. One patient suffered acute GI upset and transient lower cranial neuropathy.

Conclusion: Stereotactic radiosurgery is an effective alternative for patients with GJT in achieving tumor control and resolution of symptoms.

Ebm rating: C-4.

MeSH terms

  • Adult
  • Aged
  • Cranial Nerve Diseases / etiology
  • Female
  • Follow-Up Studies
  • Glomus Jugulare Tumor / diagnosis
  • Glomus Jugulare Tumor / surgery*
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Postoperative Complications
  • Postoperative Nausea and Vomiting / etiology
  • Prospective Studies
  • Radiosurgery*
  • Remission Induction
  • Retrospective Studies
  • Treatment Outcome
  • Vertigo / etiology