Immune reconstitution inflammatory syndrome producing atypical presentations of cryptococcal meningitis: case report and a review of immune reconstitution-associated cryptococcal infections

Scand J Infect Dis. 2006;38(3):219-21. doi: 10.1080/00365540500333996.


Atypical presentations of cryptococcal infection have been described as manifestations of immune reconstitution in HIV-infected patients following introduction of antiretroviral therapy. We describe a patient presenting with cryptococcal meningitis as an immune reconstitution reaction 10 weeks after initiation of anti-retroviral therapy. Subclinical CSF cryptococcal infection was demonstrated and the serum cryptococcal antigen was negative.

Publication types

  • Case Reports
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / immunology
  • AIDS-Related Opportunistic Infections / microbiology
  • AIDS-Related Opportunistic Infections / pathology
  • Adult
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Cerebrospinal Fluid / microbiology
  • Cryptococcus neoformans / isolation & purification
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • Humans
  • Male
  • Meningitis, Cryptococcal / immunology*
  • Meningitis, Cryptococcal / microbiology
  • Meningitis, Cryptococcal / pathology*
  • Syndrome