Utility of second derivative of the finger photoplethysmogram for the estimation of the risk of coronary heart disease in the general population

Circ J. 2006 Mar;70(3):304-10. doi: 10.1253/circj.70.304.


Background: Increased arterial stiffness has been shown to be associated with coronary heart disease (CHD). However, it remains unclear as to whether the second derivative of the finger photoplethysmogram (SDPTG), a non-invasive method for the assessment of arterial stiffness, is useful for the estimation of risk of CHD in the general population.

Methods and results: The SDPTG in 211 subjects (age: 63+/-15 years, range: 21-91 years, 93 males) was recorded without apparent atherosclerotic disorders from a community. The relationship between the SDPTG indices (b/a and d/a) and coronary risk factors (n=211) or the Framingham risk score (n=158, age: 60+/-12 years, range: 30-74 years, 63 males) were analyzed. The SDPTG indices significantly correlated with the Framingham risk score in both genders (b/a; r(male) =0.43, r(female) =0.54 and d/a; r(male) =-0.38, r(female) =-0.58), as well as several coronary risk factors. In the receiver operating characteristics curve analyses, the b/a discriminated high-risk subjects for CHD, who were in the highest quintile of the Framingham risk score in each gender, with a sensitivity and specificity of 0.85 and 0.58 in males and 0.83 and 0.72 in females, respectively.

Conclusions: These results suggest that the SDPTG is useful for the estimation of risk of CHD in the general population.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Arteriosclerosis / diagnosis
  • Arteriosclerosis / epidemiology
  • Arteriosclerosis / physiopathology
  • Blood Circulation / physiology
  • Coronary Disease / diagnosis*
  • Coronary Disease / epidemiology
  • Coronary Disease / physiopathology
  • Cross-Sectional Studies
  • Data Interpretation, Statistical
  • Female
  • Fingers / blood supply*
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Photoplethysmography / methods*
  • Photoplethysmography / standards
  • Photoplethysmography / statistics & numerical data*
  • Risk Assessment / statistics & numerical data
  • Risk Factors
  • Sensitivity and Specificity