[Cycloid psychoses as atypical manic-depressive disorders. Results of a family study]

Nervenarzt. 2006 Sep;77(9):1096-100, 1102-4. doi: 10.1007/s00115-006-2077-z.
[Article in German]


Background: Whereas a growing body of evidence suggests that cycloid psychoses have to be separated from schizophrenic psychoses, their relations to bipolar affective disorder are less clear.

Patients and methods: In a controlled family study, we recruited 46 patients with cycloid psychosis (CP), 33 with manic-depressive illness (MDI), and 27 controls. Three hundred fifty-six of 389 living first-degree relatives were personally examined by experienced psychiatrists blinded to the diagnosis of the index proband.

Results: The relatives of CP patients showed significantly lower morbidity risk of functional psychoses than relatives of patients with MDI in Kaplan-Meier life table calculation. The morbidity risk for functional psychoses in relatives of patients with CP did not differ significantly from that in relatives of controls.

Conclusion: These results suggest that CP are etiologically different from bipolar affective psychoses and cannot be integrated into the spectrum of bipolar affective disorders. The findings provide further evidence for a nosological independence of CP.

Publication types

  • English Abstract

MeSH terms

  • Adult
  • Affective Disorders, Psychotic / diagnosis
  • Affective Disorders, Psychotic / genetics*
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / genetics*
  • Cyclothymic Disorder / diagnosis
  • Cyclothymic Disorder / genetics*
  • Diagnosis, Differential
  • Female
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Life Tables
  • Male
  • Phenotype
  • Risk Assessment
  • Statistics as Topic