Dietary supplements of vitamins E and C and beta-carotene reduce oxidative stress in cats with renal insufficiency

Vet Res Commun. 2006 May;30(4):403-13. doi: 10.1007/s11259-006-3269-5.


Oxidative stress may contribute to the progression of chronic renal failure. In this study, cats with spontaneous renal insufficiency were fed a dry cat food supplemented with the antioxidants vitamins E and C, and beta-carotene for 4 weeks. When compared with healthy cats, cats with renal insufficiency had a tendency to oxidative stress. The antioxidant supplements significantly reduced DNA damage in cats with renal insufficiency as evidenced by reduced serum 8-OHdG and comet assay parameters. Therefore, supplements of vitamins E and C and beta-carotene as antioxidants may be beneficial to cats with renal disease.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Animal Feed
  • Animals
  • Antioxidants / therapeutic use
  • Ascorbic Acid / therapeutic use*
  • Biomarkers
  • Blood Urea Nitrogen
  • Cat Diseases / drug therapy*
  • Cats
  • Creatinine / blood
  • Cross-Over Studies
  • Dietary Supplements*
  • Female
  • Kidney Failure, Chronic / drug therapy
  • Kidney Failure, Chronic / veterinary*
  • Male
  • Oxidative Stress / drug effects*
  • Phosphorus / blood
  • Vitamin E / therapeutic use*
  • beta Carotene / therapeutic use*


  • Antioxidants
  • Biomarkers
  • beta Carotene
  • Vitamin E
  • Phosphorus
  • Creatinine
  • Ascorbic Acid