Acquisition and quantitation in proton spectroscopy

NMR Biomed. 1991 Apr;4(2):64-9. doi: 10.1002/nbm.1940040206.


Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the 1H NMR signal, a spatial resolution of 7 X 7 X 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N-acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.

Publication types

  • Review

MeSH terms

  • Brain / anatomy & histology
  • Brain Chemistry / physiology
  • Brain Diseases / diagnosis*
  • Brain Neoplasms / diagnosis
  • Humans
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / methods*
  • Protons
  • Water / chemistry


  • Protons
  • Water