High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy

Muscle Nerve. 2006 Aug;34(2):246-50. doi: 10.1002/mus.20524.


Patients with multifocal motor neuropathy (MMN) respond to intravenous immune globulin (IVIg) and cyclophosphamide, although the benefit is not sustained. High-dose cyclophosphamide can induce a remission in patients with autoimmune diseases, including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We describe a patient with refractory MMN who improved with high-dose cyclophosphamide (50 mg/kg for 4 days) without stem cell rescue. Following treatment she discontinued IVIg. At a 6-month examination, her strength had improved and she had regained the ability to write. High-dose cyclophosphamide may be a successful treatment for patients with MMN refractory to other therapies.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Cyclophosphamide / therapeutic use*
  • Drug Resistance
  • Evoked Potentials, Motor / physiology
  • Female
  • Humans
  • Leukocyte Count
  • Middle Aged
  • Motor Neuron Disease / drug therapy*
  • Motor Neuron Disease / physiopathology
  • Neural Conduction / physiology
  • Neurologic Examination
  • Neutrophils / physiology
  • Peripheral Nerves / physiopathology


  • Antineoplastic Agents
  • Cyclophosphamide