Primary Gougerot-Sjögren syndrome: a dermatological approach

J Eur Acad Dermatol Venereol. 2006 Mar;20(3):243-7. doi: 10.1111/j.1468-3083.2006.01441.x.


Gougerot-Sjögren syndrome (GSS) is a chronic heterogeneous non-organ-specific autoimmune disease, encompassing a wide spectrum of clinical manifestations. It is characterized by a lymphocytic infiltration of the exocrine glands, also called epitheliitis, resulting in xerostomia and keratoconjunctivitis sicca. The skin can also be involved; for example, xerosis is a consequence of epitheliitis. Dermatological consequences of polyclonal reactivity are vasculitis and manifestations of B-cell proliferation vary from plasma cell infiltrates to B-cell lymphoma.

Publication types

  • Review

MeSH terms

  • Humans
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / diagnosis*
  • Sjogren's Syndrome / pathology
  • Skin Diseases / etiology*
  • Skin Diseases / pathology