Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial

Rheum Dis Clin North Am. 2006 Feb;32(1):217-34, xi-xii. doi: 10.1016/j.rdc.2005.11.002.


Little effort has gone into the development of more effective analgesics for osteoarthritic pain. Efforts to improve symptomatic therapy for osteoarthritis have been deflected or diluted by a decision to pursue the development of disease-modifying OA drugs (DMOADs). These agents' main mechanism of action is directed not at the relief of joint pain but at slowing the progression of structural damage. This article describes the results of a recent randomized placebo-controlled designed to examine the DMOAD effect in humans of the tetracycline antibiotic doxycycline, and reviews the experience gained from other recent DMOAD trials in humans.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Doxycycline / therapeutic use*
  • Female
  • Humans
  • Matrix Metalloproteinase Inhibitors
  • Middle Aged
  • Osteoarthritis, Knee / diagnostic imaging
  • Osteoarthritis, Knee / drug therapy*
  • Pain Measurement
  • Patient Compliance
  • Radiography
  • Randomized Controlled Trials as Topic
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Matrix Metalloproteinase Inhibitors
  • Doxycycline