Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):e56-60. doi: 10.1016/j.tripleo.2005.07.011.


Platelet-rich fibrin (PRF) belongs to a new generation of platelet concentrates, with simplified processing and without biochemical blood handling. In this fourth article, investigation is made into the previously evaluated biology of PRF with the first established clinical results, to determine the potential fields of application for this biomaterial. The reasoning is structured around 4 fundamental events of cicatrization, namely, angiogenesis, immune control, circulating stem cells trapping, and wound-covering epithelialization. All of the known clinical applications of PRF highlight an accelerated tissue cicatrization due to the development of effective neovascularization, accelerated wound closing with fast cicatricial tissue remodelling, and nearly total absence of infectious events. This initial research therefore makes it possible to plan several future PRF applications, including plastic and bone surgery, provided that the real effects are evaluated both impartially and rigorously.

MeSH terms

  • Blood Platelets* / physiology
  • Bone Regeneration / drug effects
  • Cell Movement / drug effects
  • Cicatrix / physiopathology
  • Epithelium / physiology
  • Fibrin / pharmacology*
  • Fibrin Tissue Adhesive / pharmacology*
  • Fibroblasts / physiology
  • Gels
  • Hemostatics / pharmacology*
  • Humans
  • Leukocytes / immunology
  • Mesenchymal Stem Cells / physiology
  • Neovascularization, Physiologic / physiology
  • Platelet Aggregation / physiology
  • Tooth Socket / drug effects*
  • Wound Healing / drug effects*
  • Wound Healing / physiology


  • Fibrin Tissue Adhesive
  • Gels
  • Hemostatics
  • Fibrin