Rice bran fractions improve blood pressure, lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats

J Agric Food Chem. 2006 Mar 8;54(5):1914-20. doi: 10.1021/jf052561l.

Abstract

Effect of dietary supplementation of two types of rice bran fraction on blood pressure (BP), lipid profile, and glucose metabolism in stroke-prone spontaneously hypertensive rats was studied. Male 4-week-old rats were divided into one group fed the AIN-93M-based control (C) diet and two groups fed diet supplemented with 60 g/kg of Driselase and ethanol fractions (DF and EF, respectively) of rice bran. After 8 weeks feeding, the BP decreased in the DF and EF groups in comparison with the C group (p < 0.01). Plasma ACE inhibitory activity, BUN, BUN/creatinine ratio, albumin, triglyceride, and glucose levels were lower in the DF and EF groups than in the C group (p < 0.01). Plasma nitric oxide and urinary 8-hydroxy-2'-deoxyguanosine levels were lower in the DF and EF groups than in the C group (p < 0.01). Rice bran fractions appear to have a beneficial dietary component that improves hypertension, hyperlipidemia, and hyperglycemia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2'-Deoxyguanosine
  • Animals
  • Blood Glucose / metabolism*
  • Blood Pressure*
  • Catechin / analysis
  • Deoxyguanosine / analogs & derivatives
  • Deoxyguanosine / urine
  • Diet*
  • Ethanol
  • Fungal Proteins
  • Gallic Acid / analysis
  • Glycoside Hydrolases
  • Hypertension / therapy*
  • Lipids / blood*
  • Male
  • Nitric Oxide / blood
  • Nitric Oxide / urine
  • Oryza / chemistry*
  • Rats
  • Rats, Inbred SHR
  • Stroke

Substances

  • Blood Glucose
  • Fungal Proteins
  • Lipids
  • Nitric Oxide
  • Ethanol
  • Gallic Acid
  • 8-Hydroxy-2'-Deoxyguanosine
  • Catechin
  • Glycoside Hydrolases
  • driselase
  • Deoxyguanosine