Abstract
The CH2Cl2/MeOH extract of the stem bark of Oriciopsis glaberrima ENGL. afforded four new acridone alkaloids namely oriciacridone C, D, E and F along with six known compounds: atalaphyllidine, oleanolic acid, butulinic acid, beta-sitosterol, stigmasterol, glucoside of stigmasterol and one synthetically known acridone: 1,3,5-trihydroxy-4-prenylacridone. The structures were established on the basis of MS, 1D and 2D NMR experiments. The acridones 1, 4 and 5 showed potent activity against alpha-glucosidase, while the acridones 1-5 showed moderate free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acridines / chemistry*
-
Acridines / pharmacology*
-
Alkaloids / chemistry*
-
Alkaloids / pharmacology*
-
Antioxidants / pharmacology*
-
Biphenyl Compounds
-
Carbohydrate Sequence
-
Enzyme Inhibitors / pharmacology*
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / pharmacology
-
Glycoside Hydrolase Inhibitors*
-
Magnetic Resonance Spectroscopy
-
Mass Spectrometry
-
Molecular Sequence Data
-
Picrates / chemistry
-
Plant Bark / chemistry
-
Plant Stems / chemistry
-
Rutaceae / chemistry*
-
Saccharomyces cerevisiae / enzymology
-
Spectrometry, Mass, Electrospray Ionization
-
Spectrophotometry, Ultraviolet
Substances
-
Acridines
-
Alkaloids
-
Antioxidants
-
Biphenyl Compounds
-
Enzyme Inhibitors
-
Free Radical Scavengers
-
Glycoside Hydrolase Inhibitors
-
Picrates
-
1,1-diphenyl-2-picrylhydrazyl