Alpha-glucosidase inhibitory and antioxidant acridone alkaloids from the stem bark of Oriciopsis glaberrima ENGL. (Rutaceae)

Chem Pharm Bull (Tokyo). 2006 Mar;54(3):292-6. doi: 10.1248/cpb.54.292.

Abstract

The CH2Cl2/MeOH extract of the stem bark of Oriciopsis glaberrima ENGL. afforded four new acridone alkaloids namely oriciacridone C, D, E and F along with six known compounds: atalaphyllidine, oleanolic acid, butulinic acid, beta-sitosterol, stigmasterol, glucoside of stigmasterol and one synthetically known acridone: 1,3,5-trihydroxy-4-prenylacridone. The structures were established on the basis of MS, 1D and 2D NMR experiments. The acridones 1, 4 and 5 showed potent activity against alpha-glucosidase, while the acridones 1-5 showed moderate free radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridines / chemistry*
  • Acridines / pharmacology*
  • Alkaloids / chemistry*
  • Alkaloids / pharmacology*
  • Antioxidants / pharmacology*
  • Biphenyl Compounds
  • Carbohydrate Sequence
  • Enzyme Inhibitors / pharmacology*
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / pharmacology
  • Glycoside Hydrolase Inhibitors*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Sequence Data
  • Picrates / chemistry
  • Plant Bark / chemistry
  • Plant Stems / chemistry
  • Rutaceae / chemistry*
  • Saccharomyces cerevisiae / enzymology
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet

Substances

  • Acridines
  • Alkaloids
  • Antioxidants
  • Biphenyl Compounds
  • Enzyme Inhibitors
  • Free Radical Scavengers
  • Glycoside Hydrolase Inhibitors
  • Picrates
  • 1,1-diphenyl-2-picrylhydrazyl