Successful alpha-1 receptor blockade therapy in a toddler with infrequent and difficult voiding

Adv Ther. 2005 Nov-Dec;22(6):543-7. doi: 10.1007/BF02849948.

Abstract

A 3-year-old neurologically intact and behaviorally normal boy developed infrequent and difficult voiding subsequent to a soft tissue injury to the glans penis. Symptoms persisted for at least 9 months, and the course was complicated by diagnostic imaging evidence of a "markedly distended" bladder and a voiding diary that suggested elevated bladder volumes. Treatment with an alpha-1 receptor blocker normalized voiding within 24 hours. Discontinuation of the medication after 2 weeks resulted in recurrence of symptoms within 48 hours. Readministration of the medication resulted in prompt resolution of symptoms.

Publication types

  • Case Reports

MeSH terms

  • Adrenergic alpha-1 Receptor Antagonists*
  • Child, Preschool
  • Doxazosin / therapeutic use*
  • Humans
  • Male
  • Penis / injuries
  • Urinary Retention / drug therapy*
  • Urinary Retention / etiology

Substances

  • Adrenergic alpha-1 Receptor Antagonists
  • Doxazosin