PGC-1 coactivators: inducible regulators of energy metabolism in health and disease

J Clin Invest. 2006 Mar;116(3):615-22. doi: 10.1172/JCI27794.


Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / genetics
  • Diabetes Mellitus / metabolism*
  • Energy Metabolism / genetics
  • Energy Metabolism / physiology*
  • Heart Diseases / genetics
  • Heart Diseases / metabolism*
  • Humans
  • Liver / metabolism*
  • Muscle, Skeletal / metabolism*
  • Transcription Factors / genetics
  • Transcription Factors / physiology*


  • Transcription Factors
  • peroxisome-proliferator-activated receptor-gamma coactivator-1