Axillary ultrasonography to detect recurrence after sentinel node biopsy in breast cancer

Ann Surg Oncol. 2006 Apr;13(4):501-7. doi: 10.1245/ASO.2006.05.015. Epub 2006 Feb 28.

Abstract

Background: Sentinel node biopsy (SNB) for breast cancer has a false-negative rate of approximately 5%. Initial reports of follow-up show lower axillary recurrence rates than expected. We performed axillary ultrasonography to determine whether occult recurrences could be detected.

Methods: In a community hospital setting, 289 patients who had SNB for breast cancer in a single surgeon's practice underwent axillary examination by the surgeon followed by axillary ultrasonography by a dedicated breast radiologist. Ultrasonography was performed one time from 4 to 79 months (median, 25 months) after surgery. Five patients with suspicious nodes had ultrasound-guided fine-needle aspiration, and one had a core biopsy.

Results: No patient had suspicious nodes on clinical examination. Only six patients had ultrasound findings that warranted intervention. Five patients had benign cytological characteristics, and one had a benign core biopsy result. No evidence of axillary recurrence was found in any patient.

Conclusions: Axillary ultrasonography did not detect occult metastases in any patient and is not recommended for routine follow-up after SNB. The lack of ultrasound evidence of metastasis suggests that the recurrence rate is likely to remain low.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Axilla / diagnostic imaging
  • Axilla / pathology*
  • Biopsy, Fine-Needle
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / pathology*
  • False Negative Reactions
  • Female
  • Humans
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Sentinel Lymph Node Biopsy*
  • Ultrasonography