[Proinflammatory cytokines in children with migraine with or without aura]

Przegl Lek. 2005;62(11):1276-80.
[Article in Polish]


Objectives: Migraine is an idiopathic headache of differential pathogenesis.

The aim: The aim of this research was to establish whether the pathogenesis of migraine with or without aura is identical. In order to examine this, the differences in the level of interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor (TNF) and soluble TNF receptor type I (sTNFRI) were established during a migraine attack with or without aura in children.

Materials and methods: 30 children with migraine were included, 17 boys and 13 girls aged 10-17 (mean 13.5). In 14/30 children migraine without aura was diagnosed, in 16/30 with aura, visual in 12 and sensory in 4 children. The headache duration was in 23 children shorter and in 7 children longer than 6 hours. When the pain started during hospitalization, the blood was sampled in the first hour of the headache, then 3 hours and 6 hours since headache started (if headache persisted), and 6 hours after its termination. Two days after pain termination, the blood samples were collected, as the headache-free measurements. The levels of IL-6, IL-1 beta, TNF and sTNFRI were established using Biosource kits, all 146 samples were processed. The statistical assessment was conducted.

Results: The significant differences in cytokine levels were detected between children with migraine with or without aura. During headache-free interval in children without aura the level of IL1-beta was higher than with aura (p = 0.03), during 1st hour of migraine attack as well (p = 0.046). Higher, but non significant was IL-1 beta level 3 hours since headache started and 6 hours after its termination (p = 0.06). Type of migraine influenced also the TNF level (in children with migraine without aura higher 6 hours after pain termination, p = 0.046) and sTNFRI (p = 0.07 during the same period). The differences in IL-6 levels between children with migraine with or without aura were not significant.

Conclusion: 1. The significant increase in IL-1beta level observed during headache-free interval and early stage of attack of migraine without aura as compared to migraine with aura may reflect differences in pathogenesis of both types of migraine in developmental age. 2. This dissimilarity may be suggested also by the increase in TNF and sTNFRI levels in children with migraine without aura as compared to children with migraine with aura after pain termination.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Child
  • Epilepsy / immunology*
  • Female
  • Humans
  • Interleukin-1 / immunology*
  • Interleukin-6 / immunology*
  • Male
  • Migraine Disorders / epidemiology
  • Migraine Disorders / immunology*
  • Migraine Disorders / physiopathology*
  • Prevalence
  • Receptors, Tumor Necrosis Factor, Type I / immunology*


  • Interleukin-1
  • Interleukin-6
  • Receptors, Tumor Necrosis Factor, Type I