Periodontal debridement with povidone-iodine in periodontal treatment: short-term clinical and biochemical observations

J Periodontol. 2006 Mar;77(3):498-505. doi: 10.1902/jop.2006.050154.


Background: The aim of the present study was to evaluate the clinical effects of one-stage periodontal debridement with an ultrasonic instrument, associated with 0.5% povidone (pvp)-iodine irrigation in patients with chronic periodontitis.

Methods: Forty-five patients were randomly assigned into three groups: the control group (CG) received quadrant root planing at 1-week intervals over four consecutive sessions; the periodontal debridement plus pvp-iodine group (PD-PIG) received a 45-minute full-mouth debridement with an ultrasonic instrument, associated with 0.5% pvp-iodine irrigation; and the periodontal debridement group (PDG) received a 45-minute full-mouth periodontal debridement with an ultrasonic instrument, associated with NaCl irrigation.

Results: At the 3-month evaluation, the mean probing depth (PD) reduction in CG was 2.51+/-0.52 mm, 2.53+/-0.50 mm in PD-PIG, and 2.58+/-0.60 mm in PDG (P<0.05). The clinical attachment level (CAL) analysis showed a statistically significant gain in all groups compared to baseline (1.87+/-0.56 mm [CG], 1.94+/-0.70 mm [PD-PIG], and 1.99+/-0.92 mm [PDG]). Intergroup analysis of PD and CAL at 1 and 3 months showed no differences (P>0.05). The N-benzoyl-L-arginine-p-nitroanilide (BAPNA) test showed a significant reduction in trypsin activity only during the first month (P<0.05); at 3 months there were no differences compared to baseline (P=0.80).

Conclusion: This study provides no evidence that pvp-iodine is effective as an adjunct for one-stage periodontal debridement.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Analysis of Variance
  • Anti-Infective Agents, Local / therapeutic use*
  • Benzoylarginine Nitroanilide
  • Chronic Disease
  • Dental Plaque / enzymology
  • Dental Scaling / methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Periodontal Index
  • Periodontitis / drug therapy*
  • Periodontitis / therapy
  • Povidone-Iodine / therapeutic use*
  • Prospective Studies
  • Single-Blind Method
  • Statistics, Nonparametric
  • Treatment Outcome
  • Ultrasonic Therapy / instrumentation


  • Anti-Infective Agents, Local
  • Povidone-Iodine
  • Benzoylarginine Nitroanilide