Array-based methods for diagnosis and prevention of transplant rejection

Qiuheng Zhang; Elaine F Reed

doi:10.1586/14737159.6.2.165

Array-based methods for diagnosis and prevention of transplant rejection

Expert Rev Mol Diagn. 2006 Mar;6(2):165-78. doi: 10.1586/14737159.6.2.165.

Authors

Qiuheng Zhang¹, Elaine F Reed

Affiliation

¹ Immunogenetics Center, Department of Pathology & Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. jqzhang@mednet.ucla.edu

PMID: 16512777
DOI: 10.1586/14737159.6.2.165

Abstract

DNA microarray is a microhybridization-based assay that is used to simultaneously study the expression of thousands of genes, thus providing a global view of gene expression in a tissue sample. This powerful technique has been adopted by many biomedical disciplines and will likely have a profound impact on the diagnosis, treatment and prognosis of human diseases. This review article presents an overview of the application of microarray technology to the field of solid-organ transplantation.

Publication types

Review

MeSH terms

Chemokines / metabolism
Graft Rejection / diagnosis*
Graft Rejection / prevention & control*
Heart Transplantation / methods
Humans
Immunosuppressive Agents / pharmacology
Kidney Transplantation / methods
Lung Transplantation / methods
Matrix Metalloproteinases / metabolism
Molecular Diagnostic Techniques*
Nucleic Acid Hybridization
Oligonucleotide Array Sequence Analysis / methods*
T-Lymphocytes / metabolism

Substances

Chemokines
Immunosuppressive Agents
Matrix Metalloproteinases