Beneficial effects of Zingiber officinale on goldthioglucose induced obesity

Fitoterapia. 2006 Apr;77(3):160-3. doi: 10.1016/j.fitote.2006.01.005. Epub 2006 Feb 28.

Abstract

Goldthioglucose induces in mice a significant increase in body weight, glucose, insulin and lipid levels. Treatment with 250 mg/kg of methanol and ethyl acetate extracts of Zingiber officinale for 8 weeks produces significant reduction in body weight, glucose, insulin and lipid levels as compared to obese control mice. The reduction in elevated glucose along with elevated insulin levels indicates that the treatment with Z. officinale improves insulin sensitivity.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates / chemistry
  • Animals
  • Aurothioglucose / administration & dosage
  • Aurothioglucose / toxicity
  • Blood Glucose / drug effects
  • Body Weight / drug effects
  • Female
  • Ginger / chemistry*
  • Insulin / blood
  • Lipids / blood
  • Methanol / chemistry
  • Mice
  • Obesity / chemically induced
  • Obesity / drug therapy*
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use

Substances

  • Acetates
  • Blood Glucose
  • Insulin
  • Lipids
  • Plant Extracts
  • Aurothioglucose
  • ethyl acetate
  • Methanol