Fibroblast growth factor 23: the making of a hormone

Kidney Int. 2006 Feb;69(3):425-7. doi: 10.1038/sj.ki.5000168.

Abstract

Fibroblast growth factor 23 (FGF23) modulates serum phosphate and 1alpha,25-dihydroxyvitamin D3 levels. FGF23 expression is in turn regulated by 1alpha,25-dihydroxyvitamin D3 and dietary phosphate load, and is strikingly elevated during renal progression. In this issue, Nagano and colleagues report that FGF23 can be modulated by intermittently high dietary phosphate in the presence of compromised renal function.

Publication types

  • Comment

MeSH terms

  • Animals
  • Calcitriol / blood*
  • Calcitriol / physiology
  • Calcium / blood
  • Fibroblast Growth Factors / blood*
  • Fibroblast Growth Factors / genetics
  • Gene Expression Regulation
  • Homeostasis
  • Kidney / physiopathology
  • Male
  • Models, Biological
  • Parathyroid Hormone / blood
  • Phosphates / administration & dosage
  • Phosphates / blood*
  • Phosphorus, Dietary / administration & dosage*
  • Phosphorus, Dietary / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Renal Insufficiency / etiology
  • Renal Insufficiency / physiopathology

Substances

  • Parathyroid Hormone
  • Phosphates
  • Phosphorus, Dietary
  • Fibroblast Growth Factors
  • fibroblast growth factor 23
  • Calcitriol
  • Calcium