Gallbladder disease is associated with insulin resistance in a high risk Hispanic population

J Hepatol. 2006 Aug;45(2):299-305. doi: 10.1016/j.jhep.2006.01.026. Epub 2006 Feb 17.


Background/aims: We tested whether cholesterol gallstone disease (GS) is associated to insulin resistance and serum C-reactive protein (CRP) in a high risk population.

Methods: This was a nested case-control study on 881 Chilean subjects that included clinical examination, abdominal ultrasound and blood chemistries. Insulin resistance was determined by the homeostasis model assessment index (IR-HOMA).

Results: Compared to controls (n = 582), age and sex adjusted median IR-(HOMA) was significantly elevated in subjects with GS (n = 299) (P < 0.001). Risks of GS in subjects with insulin resistance and different body mass index (BMI) were: BMI < 25, 2.2 (1.1-4.7); BMI 25-30, 1.5 (0.9-2.5) and BMI > 30, 1.7 (1.0-2.9). Risk of GS in subjects with metabolic syndrome was 1.7 (CI, 1.2-2.5) and with fatty liver, 1.5 (1.1-2.2). Risk of GS in subjects with CRP > 1 mg/dL was 1.0 (0.7-1.7).

Conclusions: GS is associated to insulin resistance, fatty liver and to metabolic syndrome, but not to serum CRP in a high risk Hispanic population. Insulin resistance could have a major role in the pathogenesis of GS favoring the production of cholesterol supersaturated bile and altering gallbladder function.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Body Mass Index
  • C-Reactive Protein / metabolism
  • Chile / epidemiology
  • Female
  • Gallbladder Diseases* / blood
  • Gallbladder Diseases* / epidemiology
  • Gallbladder Diseases* / etiology
  • Humans
  • Incidence
  • Insulin / blood*
  • Insulin Resistance / physiology*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors


  • Insulin
  • C-Reactive Protein