[Mechanisms of acquired resistance to DNA topoisomerase I inhibitors]

Gan To Kagaku Ryoho. 1991 Aug;18(10):1562-7.
[Article in Japanese]

Abstract

The mechanisms of acquired resistance to mammalian DNA topoisomerase I inhibitor, camptothecin or its derivative (CPT-11) were described. Tumor cell lines containing altered or reduced topoisomerase I were reviewed. It might be necessary to further study on reduced inhibitor uptake and other unknown mechanism.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Camptothecin / analogs & derivatives*
  • Camptothecin / pharmacology
  • Doxorubicin / pharmacology
  • Drug Resistance
  • Humans
  • Irinotecan
  • Leukemia, Experimental / drug therapy
  • Leukemia, Experimental / pathology
  • Topoisomerase I Inhibitors*
  • Tumor Cells, Cultured / drug effects*

Substances

  • Antineoplastic Agents, Phytogenic
  • Topoisomerase I Inhibitors
  • Irinotecan
  • Doxorubicin
  • Camptothecin