Abstract
The mechanisms of acquired resistance to mammalian DNA topoisomerase I inhibitor, camptothecin or its derivative (CPT-11) were described. Tumor cell lines containing altered or reduced topoisomerase I were reviewed. It might be necessary to further study on reduced inhibitor uptake and other unknown mechanism.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / pharmacology*
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Camptothecin / analogs & derivatives*
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Camptothecin / pharmacology
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Doxorubicin / pharmacology
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Drug Resistance
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Humans
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Irinotecan
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Leukemia, Experimental / drug therapy
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Leukemia, Experimental / pathology
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Topoisomerase I Inhibitors*
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Tumor Cells, Cultured / drug effects*
Substances
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Antineoplastic Agents, Phytogenic
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Topoisomerase I Inhibitors
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Irinotecan
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Doxorubicin
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Camptothecin