Bruno: a double turn-off for Oskar

Dev Cell. 2006 Mar;10(3):280-1. doi: 10.1016/j.devcel.2006.02.001.


In Drosophila, the posterior localization of oskar mRNA and its translational regulation are essential for axis specification and germline formation. Recently in Cell, demonstrated that Bruno inhibits cap-dependent translation of oskar mRNA and uncovered a novel Bruno-dependent assembly of oskar mRNA into multimeric RNP particles, which are inaccessible to the translational machinery. This work provides a novel link between mRNA localization, particle formation, and translational regulation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Drosophila Proteins / genetics
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / physiology*
  • Gene Silencing
  • Protein Biosynthesis
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism*


  • Drosophila Proteins
  • RNA, Messenger
  • RNA-Binding Proteins
  • bru1 protein, Drosophila
  • osk protein, Drosophila