A randomised controlled study of the reactogenicity of an acellular pertussis-containing pentavalent infant vaccine compared to a quadrivalent whole cell pertussis-containing vaccine and oral poliomyelitis vaccine, when given concurrently with meningococcal group C conjugate vaccine to healthy UK infants at 2, 3 and 4 months of age

Vaccine. 2006 May 1;24(18):3964-70. doi: 10.1016/j.vaccine.2006.02.018. Epub 2006 Feb 21.


Two hundred forty-one healthy infants were enrolled in an open randomised controlled study of three doses of DTaP-IPV-Hib (Group 1) or DTwP/Hib+OPV (Group 2) at 2, 3 and 4 months of age given concurrently with a meningitis C conjugate vaccine. After each dose, local reactions (any grade) were less common in Group 1 than Group 2 (p<0.03). Axillary temperature >37.5 degrees C, decreased feeding, reduced activity, irritability and crying in the week after vaccination were also less common in Group 1 than Group 2 (p<0.05 for each symptom, all doses combined). Severe local reactions and systemic symptoms were uncommon and occurred equally in both groups. The pentavalent DTaP-IPV-Hib vaccine was less reactogenic than the quadrivalent DTwP-Hib vaccine, as expected when changing from whole cell pertussis (wP) to an acellular pertussis (aP) component.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / adverse effects*
  • Body Temperature
  • Crying
  • Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
  • Diphtheria-Tetanus-Pertussis Vaccine / adverse effects*
  • Feeding Behavior
  • Female
  • Humans
  • Infant
  • Irritable Mood
  • Male
  • Meningococcal Vaccines / administration & dosage*
  • Motor Activity
  • Poliovirus Vaccine, Inactivated
  • Poliovirus Vaccine, Oral / administration & dosage
  • Poliovirus Vaccine, Oral / adverse effects
  • United Kingdom
  • Vaccines, Acellular / administration & dosage
  • Vaccines, Acellular / adverse effects*
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / adverse effects


  • Bacterial Vaccines
  • DT5aP-Hib-IPV vaccine
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Meningococcal Vaccines
  • Poliovirus Vaccine, Inactivated
  • Poliovirus Vaccine, Oral
  • Vaccines, Acellular
  • Vaccines, Combined
  • serogroup C meningococcal conjugate vaccine