Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities

Colloids Surf B Biointerfaces. 2006 Mar 15;48(2):112-8. doi: 10.1016/j.colsurfb.2006.01.006. Epub 2006 Mar 6.


Gold nanoparticles were loaded in the bilayer of dipalmitoylphosphatidylcholine (DPPC) liposomes, named as gold-loaded liposomes. Above the gel to liquid-crystalline phase transition temperature, membrane fluidities of DPPC liposomes were changed by loading the gold nanoparticles. Compared with liposomes without loading the gold nanoparticles, gold-loaded liposomes showed the lower fluorescence anisotropy values. That is, the membrane fluidities of DPPC bilayer were increased by loading the gold nanoparticles. The membrane fluidities were increased as the amount of gold nanoparticles increased. The existence of gold nanoparticles in the DPPC bilayer was observed by transmission electron microscopy. Through the energy dispersive X-ray spectrometer, the particles in DPPC bilayer were confirmed to be gold nanoparticles.

MeSH terms

  • 1,2-Dipalmitoylphosphatidylcholine / chemistry*
  • Electron Probe Microanalysis
  • Fluorescence Polarization
  • Gas Chromatography-Mass Spectrometry
  • Gold / chemistry*
  • Lipid Bilayers / chemistry*
  • Liposomes / chemistry
  • Membrane Fluidity*
  • Microscopy, Electron, Transmission
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Particle Size


  • Lipid Bilayers
  • Liposomes
  • 1,2-Dipalmitoylphosphatidylcholine
  • Gold