Quality of Life was assessed by the Minnesota Living With Heart Failure Questionnaire in 61 patients with Chronic Systolic Heart Failure secondary to Chagas' cardiomyopathy. Mean total score was 37.3+/-21.4, mean physical dimension score 15.3+/-9.9 and mean emotional dimension score 7.4+/-5.2. A negative correlation between total score and hemoglobin levels, Systolic and Diastolic Blood Pressure and the 6-Minute Walk Test were observed. Total score was higher in patients in Class IV, on amiodarone, furosemide and carvedilol, and in non-sinus rhythm patients. Quality of Life Assessment in chagasic patients is similar to that found in patients with nonchagasic heart failure.