Intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in patients with both Crohn's disease and intestinal resection

Am J Clin Nutr. 1991 Sep;54(3):548-52. doi: 10.1093/ajcn/54.3.548.


We compared the intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in patients with Crohn's disease and resections of the small bowel. Patients were subgrouped into those with small (less than 100 cm), intermediate (100-300 cm), and large (greater than 300 cm) resections. [3H]cholecalciferol or [3H]25-hydroxycholecalciferol were given orally and serial blood samples were taken for measurement of plasma radiolabeled vitamin. Absorption of both forms of the vitamin decreased with extent of resection but 25-hydroxycholecalciferol absorption was always greater than that of cholecalciferol. When compared with normal control subjects, 25-hydroxycholecalciferol absorption in these patients was better maintained than that of cholecalciferol. These data indicate that vitamin D malabsorption reflects the extent of distal small-bowel resection in Crohn's disease. Treatment with oral cholecalciferol is sufficient in those with small or moderate resections but oral 25-hydroxycholecalciferol supplementation may be preferred in those with a severe short-bowel syndrome.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Absorption
  • Bile Acids and Salts / metabolism
  • Calcifediol / pharmacokinetics*
  • Cholecalciferol / pharmacokinetics*
  • Crohn Disease / metabolism
  • Crohn Disease / surgery*
  • Duodenum / metabolism
  • Humans
  • Intestinal Mucosa / metabolism
  • Intestines / surgery*
  • Osmolar Concentration
  • Postoperative Period


  • Bile Acids and Salts
  • Cholecalciferol
  • Calcifediol