Anchored cAMP signaling: onward and upward - a short history of compartmentalized cAMP signal transduction

Eur J Cell Biol. 2006 Jul;85(7):585-92. doi: 10.1016/j.ejcb.2006.01.011. Epub 2006 Mar 9.


Intracellular signal transduction pathways require a high degree of spatial and temporal resolution in order to deliver the appropriate outputs. Specific signaling mediated by the ubiquitous second messenger cAMP and its effector, the cAMP-dependent protein kinase (PKA), is governed by the spatial organization of different pathway components by A-kinase anchoring proteins (AKAPs). This review discusses the history and future of anchored cAMP signaling pathways.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cell Compartmentation*
  • Cyclic AMP / history*
  • Cyclic AMP / metabolism*
  • History, 20th Century
  • History, 21st Century
  • Models, Biological
  • Signal Transduction*


  • Adaptor Proteins, Signal Transducing
  • Cyclic AMP