Expression of HER1/EGFR protein in human soft tissue sarcomas

Eur J Surg Oncol. 2006 May;32(4):466-8. doi: 10.1016/j.ejso.2006.01.012. Epub 2006 Mar 7.


Aim: To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples.

Method: HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients.

Results: HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues.

Conclusion: HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / biosynthesis*
  • ErbB Receptors / biosynthesis*
  • Female
  • Follow-Up Studies
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Sarcoma / metabolism*
  • Sarcoma / pathology
  • Severity of Illness Index


  • Biomarkers, Tumor
  • ErbB Receptors