Abstract
There are at least 3 isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, a bifunctional enzyme which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate. A 22-kb rat gene that encodes the heart isozyme has been identified and compared with the 55-kb rat gene encoding the liver and muscle isozymes which had been described earlier. Although these 2 genes include 12 successive similar exons, they contain dissimilar exons at both ends, consistent with the occurrence of different regulatory domains at the N- and C-termini in the 3 isozymes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Blotting, Southern
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Exons / genetics
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Fructosediphosphates / metabolism
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Gene Expression Regulation / physiology
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Isoenzymes / genetics
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Liver / enzymology
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Molecular Sequence Data
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Muscles / enzymology
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Myocardium / enzymology*
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Phosphofructokinase-2
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Phosphoric Monoester Hydrolases / genetics*
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Phosphotransferases / genetics*
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Rats
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Sequence Homology, Nucleic Acid
Substances
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Fructosediphosphates
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Isoenzymes
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fructose 2,6-diphosphate
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Phosphotransferases
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Phosphofructokinase-2
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Phosphoric Monoester Hydrolases
Associated data
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GENBANK/S53338
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GENBANK/X58797
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GENBANK/X58798
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GENBANK/X58799
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GENBANK/X58800
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GENBANK/X58801
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GENBANK/X58802
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GENBANK/X58803
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GENBANK/X61956
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GENBANK/X61958