A rat gene encoding heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

FEBS Lett. 1991 Aug 19;288(1-2):91-4. doi: 10.1016/0014-5793(91)81009-w.

Abstract

There are at least 3 isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, a bifunctional enzyme which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate. A 22-kb rat gene that encodes the heart isozyme has been identified and compared with the 55-kb rat gene encoding the liver and muscle isozymes which had been described earlier. Although these 2 genes include 12 successive similar exons, they contain dissimilar exons at both ends, consistent with the occurrence of different regulatory domains at the N- and C-termini in the 3 isozymes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Blotting, Southern
  • Exons / genetics
  • Fructosediphosphates / metabolism
  • Gene Expression Regulation / physiology
  • Isoenzymes / genetics
  • Liver / enzymology
  • Molecular Sequence Data
  • Muscles / enzymology
  • Myocardium / enzymology*
  • Phosphofructokinase-2
  • Phosphoric Monoester Hydrolases / genetics*
  • Phosphotransferases / genetics*
  • Rats
  • Sequence Homology, Nucleic Acid

Substances

  • Fructosediphosphates
  • Isoenzymes
  • fructose 2,6-diphosphate
  • Phosphotransferases
  • Phosphofructokinase-2
  • Phosphoric Monoester Hydrolases

Associated data

  • GENBANK/S53338
  • GENBANK/X58797
  • GENBANK/X58798
  • GENBANK/X58799
  • GENBANK/X58800
  • GENBANK/X58801
  • GENBANK/X58802
  • GENBANK/X58803
  • GENBANK/X61956
  • GENBANK/X61958