European and American subgroup C isolates of avian metapneumovirus belong to different genetic lineages

Virus Genes. 2006 Feb;32(1):97-103. doi: 10.1007/s11262-005-5850-3.


The gene encoding the attachment glycoprotein (G) was sequenced in three French isolates of-subgroup C avian metapneumovirus (APV-C) from ducks. With 1771 nt, this gene proved as long as recently published for North-American APV-C isolates from turkeys. The nt sequences of the duck viruses shared 99% identity but proved only 75-83% identical with their North-American counterparts, viruses of both origins encoding 585 amino acid (aa)-long G proteins. Alignments revealed more homogeneity within the European and North-American groups (at least 98 and 79% aa identity, respectively) than between European and North-American viruses (at best 70% a identity), and confirmed the presence of an extracellular divergent domain (positions 302-484) in APV-C G. A phylogenetic analysis demonstrated that North-American and French isolates of APV-C belonged to significantly different genetic lineages, in agreement with the different geographical origin and host species of these viruses.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Ducks
  • Europe
  • Genes, Viral
  • Metapneumovirus / classification
  • Metapneumovirus / genetics*
  • Metapneumovirus / isolation & purification
  • Molecular Sequence Data
  • North America
  • Phylogeny
  • Sequence Homology, Amino Acid
  • Viral Envelope Proteins / genetics


  • Viral Envelope Proteins
  • attachment protein G

Associated data

  • GENBANK/AJ811991
  • GENBANK/AJ811992
  • GENBANK/AJ811993