Anti-topoisomerase I antibodies in systemic lupus erythematosus as a marker of severe nephritis

Mohamed A Hamidou; Marie A Audrain; Agathe Masseau; Christian Agard; Anne Moreau

doi:10.1007/s10067-005-0061-9

Anti-topoisomerase I antibodies in systemic lupus erythematosus as a marker of severe nephritis

Clin Rheumatol. 2006 Jul;25(4):542-3. doi: 10.1007/s10067-005-0061-9. Epub 2006 Mar 7.

Authors

Mohamed A Hamidou¹, Marie A Audrain, Agathe Masseau, Christian Agard, Anne Moreau

Affiliation

¹ Department of Internal Medicine, University Hospital Hôtel-Dieu, Place Alexis Ricordeau, 44 035, Nantes, France. mohamed.hamidou@chu-nantes.fr

PMID: 16525896
DOI: 10.1007/s10067-005-0061-9

Abstract

The authors report nine patients with systemic lupus erythematosus associated with anti-topoisomerase I antibodies (ELISA test) without features of systemic sclerosis. These antibodies were correlated with the disease activity and might be a marker of the severity of the closely related to difusse proliferative glomerulonephritis.

MeSH terms

Adult
Antibodies, Monoclonal / blood*
Biomarkers / blood
DNA Topoisomerases, Type I / immunology*
Female
Follow-Up Studies
Glomerulonephritis / blood
Glomerulonephritis / diagnosis*
Glomerulonephritis / immunology*
Humans
Lupus Erythematosus, Systemic / blood
Lupus Erythematosus, Systemic / complications
Lupus Erythematosus, Systemic / immunology*
Male
Predictive Value of Tests
Prognosis
Severity of Illness Index*

Substances

Antibodies, Monoclonal
Biomarkers
DNA Topoisomerases, Type I