Oral candidosis in patients with advanced cancer

Oral Oncol. 2006 Aug;42(7):698-702. doi: 10.1016/j.oraloncology.2005.11.010. Epub 2006 Mar 9.

Abstract

The objectives of the study were to determine the epidemiology, aetiology, clinical features and microbiological aspects of oral candidosis in a cohort of cancer patients receiving specialist palliative care. One hundred and twenty patients participated in the study. Seventy-nine (66%) of the patients had microbiological evidence of oral yeast carriage, whilst 36 (30%) of the patients had combined clinical and microbiological evidence of oral candidosis. Oral candidosis was associated with a poor performance status, the presence of xerostomia, and the presence of dentures; oral candidosis was not associated with the use of oral/parenteral antibiotics, or the use of oral/parenteral corticosteroids. Candida albicans was the predominant organism isolated from the oral swabs of patients with oral candidosis. However, non-C. albicans species were the predominant organism in 25% cases, and a contributing organism in a further 19% cases.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Candida / classification
  • Candida / isolation & purification
  • Candidiasis, Oral / complications*
  • Candidiasis, Oral / diagnosis
  • Candidiasis, Oral / microbiology
  • Female
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Opportunistic Infections / complications*
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / microbiology
  • Palliative Care
  • Prospective Studies
  • Risk Factors
  • Severity of Illness Index
  • Stomatitis, Denture / complications
  • Stomatitis, Denture / microbiology
  • Xerostomia / complications