The risks and safety of clopidogrel in pediatric arterial ischemic stroke

Stroke. 2006 Apr;37(4):1120-2. doi: 10.1161/01.STR.0000209620.44017.97. Epub 2006 Mar 9.


Background and purpose: The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS). Clopidogrel is the alternative antiplatelet medication when aspirin is not tolerated or fails. The possible risks and safety of clopidogrel in children with AIS have not been assessed.

Methods: This is a prospective consecutive cohort study of children with AIS who were started on clopidogrel. Seventeen children were included.

Results: Two children developed subdural hematomas while on clopidogrel in conjunction with aspirin. Two others had headache or hand numbness. No other side effects like rash or gastrointestinal upsets were reported.

Conclusions: We found clopidogrel to be relatively well tolerated in the pediatric population. In combination with aspirin and in the presence of other risk factors, intracranial bleeding may be seen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Aspirin / adverse effects
  • Aspirin / therapeutic use
  • Brain Ischemia / complications*
  • Brain Ischemia / diagnostic imaging
  • Child
  • Child, Preschool
  • Clopidogrel
  • Cohort Studies
  • Drug Therapy, Combination
  • Hand
  • Headache / chemically induced
  • Hematoma, Subdural / chemically induced
  • Hematoma, Subdural / diagnostic imaging
  • Humans
  • Hypesthesia / chemically induced
  • Infant
  • Infant, Newborn
  • Moyamoya Disease / complications
  • Moyamoya Disease / diagnostic imaging
  • Platelet Aggregation Inhibitors / adverse effects*
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Prospective Studies
  • Stroke / drug therapy*
  • Stroke / etiology*
  • Ticlopidine / adverse effects
  • Ticlopidine / analogs & derivatives*
  • Ticlopidine / therapeutic use
  • Tomography, X-Ray Computed


  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • Ticlopidine
  • Aspirin