Who comes first? How plant pathogenic bacteria orchestrate type III secretion

Curr Opin Microbiol. 2006 Apr;9(2):193-200. doi: 10.1016/j.mib.2006.02.006. Epub 2006 Mar 9.


The type III secretion system (T3SS) is a key pathogenicity factor of many Gram-negative plant and animal pathogens and is also present in some symbiotic bacteria. T3SSs are highly conserved, complex molecular injection machines that translocate bacterial effector proteins directly into eukaryotic cells. Recent genetic, biochemical and structural studies revealed that the activity of the T3SS is regulated by common mechanisms in different bacterial species. In many cases, type III secretion is activated upon host cell contact and depends on specific control proteins, including transcriptional regulators and type III secretion chaperones.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Gram-Negative Bacteria / genetics
  • Gram-Negative Bacteria / metabolism*
  • Gram-Negative Bacteria / pathogenicity
  • Molecular Chaperones / physiology
  • Plant Proteins / genetics
  • Plants / microbiology*
  • Protein Transport
  • Symbiosis / physiology
  • Transcriptional Activation
  • Virulence


  • Bacterial Proteins
  • Molecular Chaperones
  • Plant Proteins