Endocytosis conducts the cell signaling orchestra

Cell. 2006 Mar 10;124(5):897-900. doi: 10.1016/j.cell.2006.02.025.


Endocytosis is used by eukaryotic cells to regulate nutrient internalization, signal transduction, and the composition of the plasma membrane. However, a more complex picture is emerging, in which endocytic pathways integrate diverse signals, thereby contributing to a higher level of cellular and organismal organization. In this way, endocytosis and cell signaling are intertwined in many biological processes, such as cell motility and cell fate determination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation / physiology
  • Cell Movement / physiology
  • Endocytosis / physiology*
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / physiology*
  • Signal Transduction / physiology*