Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 124 (5), 901-14

Sex Chromosome Specialization and Degeneration in Mammals

Affiliations
Review

Sex Chromosome Specialization and Degeneration in Mammals

Jennifer A Marshall Graves. Cell.

Abstract

Sex chromosomes--particularly the human Y--have been a source of fascination for decades because of their unique transmission patterns and their peculiar cytology. The outpouring of genomic data confirms that their atypical structure and gene composition break the rules of genome organization, function, and evolution. The X has been shaped by dosage differences to have a biased gene content and to be subject to inactivation in females. The Y chromosome seems to be a product of a perverse evolutionary process that does not select the fittest Y, which may cause its degradation and ultimate extinction.

Similar articles

See all similar articles

Cited by 212 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback