Salivary gland gene therapy

Dent Clin North Am. 2006 Apr;50(2):157-73, vii. doi: 10.1016/j.cden.2005.11.002.


Salivary glands have proven to be unusual but valuable target sites for multiple clinical gene transfer applications. Access to salivary glands for gene transfer is easy. Multiple studies in animal models have yielded proofs of concept for novel treatments for damaged salivary glands following therapeutic irraditation, in Sjögren's syndrome, and for gene therapeutics systemically by way of the blood-stream and locally in the oral cavity and upper gastrointestinal tract.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems / methods*
  • Genetic Therapy / methods*
  • Head and Neck Neoplasms / complications
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Proteins / genetics
  • Proteins / metabolism
  • Radiation Injuries / therapy
  • Rats
  • Salivary Gland Diseases / complications
  • Salivary Gland Diseases / therapy*
  • Salivary Glands / injuries
  • Salivary Glands / metabolism*
  • Sjogren's Syndrome / genetics
  • Sjogren's Syndrome / therapy


  • Proteins