Effect of a standardized extract of red orange juice on proliferation of human prostate cells in vitro

Fitoterapia. 2006 Apr;77(3):151-5. doi: 10.1016/j.fitote.2005.10.001. Epub 2006 Feb 23.

Abstract

A standardized extract of red orange juice (ROE) was shown to inhibit proliferation of fibroblast and epithelial prostate cells. These data suggest that the antiproliferative properties of ROE cannot be ascribed to cytotoxic effect and highlight its potential usefulness in the management of benign prostatic hyperplasia.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Artemia / drug effects
  • Biological Assay / methods
  • Cell Line
  • Cell Proliferation / drug effects*
  • Citrus sinensis / chemistry*
  • Citrus sinensis / toxicity*
  • Cricetinae
  • Cricetulus
  • Epithelial Cells / cytology
  • Epithelial Cells / drug effects
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Humans
  • Male
  • Phytotherapy
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use
  • Plant Extracts / toxicity
  • Prostate / cytology*
  • Prostate / drug effects
  • Prostatic Hyperplasia / drug therapy
  • Tetrazolium Salts / metabolism
  • Thiazoles / metabolism
  • Trypan Blue / metabolism

Substances

  • Plant Extracts
  • Tetrazolium Salts
  • Thiazoles
  • thiazolyl blue
  • Trypan Blue