A neuropeptide in immune-mediated inflammation, Y?

Trends Immunol. 2006 Apr;27(4):164-7. doi: 10.1016/j.it.2006.02.003. Epub 2006 Mar 10.


Disturbances in crosstalk between the immune system and the sympathetic nervous system (SNS) can contribute to the pathogenesis of Th1-mediated autoimmunity. Recent studies indicate that neuropeptide Y (NPY) has a major role in the regulation of Th1 responses. The precise role of NPY has been an enigma, but a recent study provides a breakthrough, demonstrating that NPY has a bimodal role as a negative regulator of T cells and an activator of antigen-presenting cell function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Neurons / immunology
  • Neurons / metabolism
  • Neuropeptide Y / deficiency
  • Neuropeptide Y / genetics
  • Neuropeptide Y / immunology*
  • Neuropeptide Y / metabolism*
  • T-Lymphocytes, Regulatory / immunology
  • Th1 Cells / immunology
  • Th1 Cells / metabolism


  • Neuropeptide Y