Sentinel lymph node mapping with technetium-99m colloidal rhenium sulfide in patients with gastric carcinoma

Am J Surg. 2006 Apr;191(4):465-9. doi: 10.1016/j.amjsurg.2005.09.002.


Background: The objective of this study was to determine, with the use of technetium-99m colloidal rhenium sulfide, whether the concept of sentinel lymph nodes (SLNs) is applicable to gastric cancers.

Methods: Fifty-nine gastric cancer patients underwent radical gastrectomy and SLN mapping with an intraoperative hand-held gamma probe. After surgery, each transected lymph node was measured for radioisotope (RI) activities by a well-type scintillation counter.

Results: SLNs were detectable in 57 (96%) of 59 patients. The sensitivity, specificity, and diagnostic accuracy were calculated to be 83.3%, 100%, and 92.9%, respectively. Sensitivity was 100% in the T1 group, 91.6% in the T2 group, and 62.5% in the T3 group. When RI activities were measured with a well-type scintillation counter, every metastatic non-SLN was found to be situated in the same lymphatic basin as the SLNs.

Conclusion: The SLN concept is applicable to patients with early gastric cancer (T1). SLN mapping is suitable for identifying the lymphatic basin in cases of gastric cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / diagnostic imaging*
  • Adenocarcinoma / pathology*
  • Adenocarcinoma / surgery
  • Adult
  • Aged
  • Female
  • Humans
  • Lymphatic Metastasis / diagnostic imaging*
  • Male
  • Middle Aged
  • Prospective Studies
  • Radionuclide Imaging
  • Radiopharmaceuticals*
  • Rhenium*
  • Sentinel Lymph Node Biopsy
  • Stomach Neoplasms / diagnostic imaging*
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery
  • Technetium Compounds*


  • Radiopharmaceuticals
  • Technetium Compounds
  • technetium Tc 99m rhenium colloid
  • Rhenium