Chronic, programmed polypeptide delivery from an implanted, multireservoir microchip device

Nat Biotechnol. 2006 Apr;24(4):437-8. doi: 10.1038/nbt1199. Epub 2006 Mar 12.


Implanted drug delivery systems are being increasingly used to realize the therapeutic potential of peptides and proteins. Here we describe the controlled pulsatile release of the polypeptide leuprolide from microchip implants over 6 months in dogs. Each microchip contains an array of discrete reservoirs from which dose delivery can be controlled by telemetry.

MeSH terms

  • Animals
  • Dogs
  • Drug Therapy, Computer-Assisted / instrumentation*
  • Drug Therapy, Computer-Assisted / methods
  • Equipment Design
  • Equipment Failure Analysis
  • Infusion Pumps, Implantable*
  • Leuprolide / administration & dosage*
  • Male
  • Microfluidic Analytical Techniques / instrumentation*
  • Microfluidic Analytical Techniques / methods
  • Miniaturization
  • Telemetry / instrumentation*


  • Leuprolide