Neuronal activity determines the protein synthesis dependence of long-term potentiation

Nat Neurosci. 2006 Apr;9(4):478-80. doi: 10.1038/nn1667. Epub 2006 Mar 12.


Long-term potentiation (LTP) is generally divided into two phases, early (E-) and late (L-) LTP, of which only L-LTP is thought to depend on protein synthesis. Here we report that E-LTP can also be dependent on protein synthesis at higher levels of synaptic activation. Moreover, we show that the requirement for protein synthesis during L-LTP extends beyond the early induction phase and that it depends on synaptic stimulation. This suggests that the level of neuronal activity is a crucial determinant for the role of protein synthesis in E- and L-LTP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anisomycin / metabolism
  • Electrophysiology
  • Long-Term Potentiation / physiology*
  • Neurons / cytology
  • Neurons / metabolism*
  • Protein Biosynthesis / physiology*
  • Protein Synthesis Inhibitors / metabolism
  • Receptors, N-Methyl-D-Aspartate / metabolism
  • Synapses / metabolism*
  • Synaptic Transmission


  • Protein Synthesis Inhibitors
  • Receptors, N-Methyl-D-Aspartate
  • Anisomycin