Drug transporters in pharmacokinetics

Naunyn Schmiedebergs Arch Pharmacol. 2006 Mar;372(6):465-75. doi: 10.1007/s00210-006-0042-9. Epub 2006 Mar 11.


This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms yielding functional carrier protein mutations. An integrated phase concept should reflect the interplay between drug metabolism and drug transport.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport
  • Blood-Brain Barrier / metabolism
  • Humans
  • Kidney / metabolism
  • Liver / metabolism
  • Membrane Transport Proteins / chemistry
  • Membrane Transport Proteins / metabolism*
  • Models, Biological
  • Pharmaceutical Preparations / metabolism*
  • Xenobiotics / metabolism
  • Xenobiotics / pharmacokinetics


  • Membrane Transport Proteins
  • Pharmaceutical Preparations
  • Xenobiotics