Diminished Susceptibility to Daptomycin Accompanied by Clinical Failure in a Patient With Methicillin-Resistant Staphylococcus Aureus Bacteremia

Infect Control Hosp Epidemiol. 2006 Mar;27(3):315-7. doi: 10.1086/502688. Epub 2006 Feb 23.


We cared for a patient with methicillin-resistant Staphylococcus aureus bacteremia who experienced clinical failure with daptomycin. The failure was accompanied by progressive elevation of the daptomycin minimum inhibitory concentration during treatment. DNA fingerprinting confirmed that the minimum inhibitory concentration elevation occurred within the same strain of methicillin-resistant Staphylococcus aureus. This observation provides important new information to clinicians who adopt this promising drug for treatment of serious infections caused by methicillin-resistant Staphylococcus aureus.

Publication types

  • Case Reports

MeSH terms

  • Aged, 80 and over
  • DNA Fingerprinting
  • Daptomycin / therapeutic use*
  • Drug Resistance, Bacterial
  • Fatal Outcome
  • Female
  • Humans
  • Methicillin Resistance*
  • Microbial Sensitivity Tests
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / physiopathology
  • Staphylococcus aureus / drug effects


  • Daptomycin