Molecular biology of actin binding proteins: evidence for a common structural domain in the F-actin binding sites of gelsolin and alpha-actinin

Abstract

We review the impact of molecular biology on actin binding proteins, in particular on sequence relationships and expression of clones to dissect properties in vitro. Significant homologies exist between proteins in each class, but we propose, in addition, that common structural features exist between the F-actin binding sites of severing and cross-linking proteins.