Efficacy of polyphenon E, red ginseng, and rapamycin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice

Neoplasia. 2006 Jan;8(1):52-8. doi: 10.1593/neo.05652.

Abstract

The objective of this investigation was to determine the efficacy of several novel agents in preventing lung tumorigenesis in mice. We evaluated polyphenon E, red ginseng, and rapamycin in A/J mice treated with the tobacco-specific carcinogen benzo(a)pyrene for their ability to inhibit pulmonary adenoma formation and growth. We found that treatment with polyphenon E exhibited a significant reduction on both tumor multiplicity and tumor load (tumor multiplicity x tumor volume) in a dose-dependent fashion. Polyphenon E (2% wt/wt) in the diet reduced tumor multiplicity by 46% and tumor load by 94%. This result provided key evidence in support of a phase II clinical chemoprevention trial of lung cancer. Administration of red ginseng in drinking water decreased tumor multiplicity by 36% and tumor load by 70%. The mammalian target of rapamycin inhibitor rapamycin showed significant efficacy against lung tumor growth in the tumor progression protocol and reduced tumor load by 84%. The results of these investigations demonstrate that polyphenon E, red ginseng, and rapamycin significantly inhibit pulmonary adenoma formation and growth in A/J mice.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adenoma / pathology
  • Animals
  • Antibiotics, Antineoplastic / pharmacology
  • Anticarcinogenic Agents / pharmacology
  • Antineoplastic Agents / pharmacology*
  • Benzo(a)pyrene / pharmacology
  • Catechin / analogs & derivatives*
  • Catechin / pharmacology
  • Female
  • Lung Neoplasms / chemically induced
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / pathology
  • Mice
  • Panax / metabolism*
  • Protein Kinases / metabolism
  • Sirolimus / pharmacology*
  • TOR Serine-Threonine Kinases
  • Tea

Substances

  • Antibiotics, Antineoplastic
  • Anticarcinogenic Agents
  • Antineoplastic Agents
  • Tea
  • Benzo(a)pyrene
  • Catechin
  • Protein Kinases
  • TOR Serine-Threonine Kinases
  • mTOR protein, mouse
  • polyphenon E
  • Sirolimus