The immuno cross-reactivity of gutta percha points

Dent Mater. 2007 Mar;23(3):380-4. doi: 10.1016/ Epub 2006 Mar 14.


Objective: The purpose of this study is to test the postulated immuno cross-reactivity between proteins derived from raw gutta percha (RGP), gutta percha point (GPP) and natural rubber latex (NRL).

Methods: Antigenicity and cross-reactivity of proteins were determined by the FITkit (FITBiotech, Finland) and ELISA inhibition assays.

Results: Antigenicity of proteins derived from RGP or GPP was not demonstrated. Except for NRL glove extracts, neither extracts from RGP or GPP were reactive in ELISA inhibition assay.

Significance: There is no immunologic cross-reactivity in vitro between proteins derived from RGP or GPP, and from NRL gloves. Thus, therapeutic use of GPP is unlikely to initiate adverse immuno-reactivity in individuals previously sensitized to NRL proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cross Reactions
  • Enzyme-Linked Immunosorbent Assay
  • Gutta-Percha*
  • Immunologic Tests
  • Latex Hypersensitivity / immunology*
  • Latex*
  • Mimusops*
  • Plant Proteins / immunology*
  • Root Canal Filling Materials*
  • Rubber*


  • Latex
  • Plant Proteins
  • Root Canal Filling Materials
  • gutta-balata
  • Gutta-Percha
  • Rubber